does l-carnitine really work Ingredient Insight: L- Carnitine You may have heard of in the fitness world… but what actually is it and why is it important? From energy production and exercise performance to recovery The bright and the dark

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Abbreviations AcAc: Acetoacetate acetyl-CoA: Acetyl coenzyme A AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis AMPK: AMP-activated protein kinase APP: Amyloid precursor protein ATP: Adenosine triphosphate A: -Amyloid Bcl-2: B-cell lymphoma 2 BDNF: Brain-derived neurotrophic factor BHB: -Hydroxybutyrate C9orf72: Chromosome 9 open reading frame 72 COX-2: Cyclooxygenase-2 D-BHB: D--Hydroxybutyrate EAE: Autoimmune encephalomyelitis HCA2: Hydroxycarboxylic acid receptor 2 HD: Huntingtons disease HMG-CoA: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA HTT: Huntingtin ILs: Interleukins KD: Ketogenic diet LPS: Lipopolysaccharides MCT: Medium-chain triglyceride MS: Multiple sclerosis mTORC1: Mammalian target of rapamycin complex 1 NADH: Nicotinamide adenine dinucleotide hydrogen NF-B: Nuclear factor kappa B NLRP3: Nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing protein 3 NMDA: N -Methyl-D-aspartate Nrf2: Nuclear factor erythroid 2-related factor 2 PD: Parkinsons disease PGC-1: Peroxisome proliferator-activated receptor coactivator 1- ROS: Reactive oxygen species SCFAs: Short-chain fatty acids SIRT1: Sirtuin-1 SOD1: Superoxide dismutase 1 TCA: Tricarboxylic acid TNF-: Necrosis factor-alpha References Dugger BN, Dickson DW

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Every arrow in this pathway has a cofactor