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A locus control region consisting of two DNase-I hypersensitive regions (HS), specifically HG-I site, 14.5 and 30 kb upstream of GH1 appears to be required for pituitary-specific GH1 expression (293)

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One of the hallmark challenges in managing sepsis is its ability to affect multiple organ systems simultaneously (Figure 1)

Studies utilizing genetic knockdowns or pharmacological inhibitors have shown that disruption of one antioxidant system often leads to compensatory upregulation and increased reliance on the other, underscoring their functional interdependence [45]

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