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In contrast, Prx3 and Prx4 were downregulated in the presence of mutant SOD1 G93A in NSC-34 cells (Kirby et al., 2005), and immunohistochemical analysis of motor neurons from sALS and fALS patients revealed negative immunoreactivity for Prx2 and glutathione peroxidase-l (Kato et al., 2005)

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