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The GutBrainMitochondria Axis in Autism The process can be understood as a biological cascade: Gut dysbiosis imbalance in the microbiome Leaky gut increased intestinal permeability Microbial metabolites enter the bloodstream Neuroinflammation and oxidative stress occur in the brain Mitochondrial dysfunction affects neuronal development This interconnected system helps explain why many children with ASD experience gastrointestinal symptoms, immune irregularities, and metabolic differences alongside neurological symptoms

Conclusion and Perspectives The commensal microbiota has critical regulatory influences on epithelial barrier function

Cunningham S, Lindberg S, Joinson C, Shoham D, Chu H, Newman D, Epperson N, Brubaker L, Low L, Camenga D , Yvette LaCoursiere D, Meister M, Kenton K, Sutcliffe S, Markland A, Gahagan S, Coyne-Beasley T, Berry A, Griffith J, Simon M, Brubaker L

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