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Abbreviations LD: Lyme disease Bb: Borrelia burgdorferi LC-MS/MS: Liquid chromatography-tandem mass spectrometry BSK-H: Barbour-Stoenner-Kelly-H RT: Room temperature NSAF: Normalized spectral abundance factors SDS: Sodium dodecyl sulfate DTT: Dithiothreitol IgG: Immunoglobulin G Serpin: Serine protease inhibitor TIL: Trypsin inhibitor-like MP: Metalloprotease AMP: Antimicrobial peptides TSP: Tick-specific proteins of unknown function RNAi: RNA interference PAR: Protease-activated receptors NPC: Niemann-Pick type C ML: MD-2-related lipid-recognition GRP: Glycine rich proteins ECM: Extracellular matrix CS: Cytoskeletal ROS: Reactive oxygen species H 2 O 2 : Hydrogen peroxide NET: Neutrophil extracellular traps ATP: Adenine triphosphate NADH: Nicotinamide adenine dinucleotide hydride HSP: Heat shock protein CRT: Calreticulin IGFBP-rP: Insulin growth factor binding proteins-related proteins OspC: Outer surface protein C ELISA: Enzyme-linked immunosorbent assay References Rosenberg R, Lindsey NP, Fischer M, Gregory CJ, Hinckley AF, Mead PS, et al

Aloe has also been proven to heal wounds, scars, and other forms of inflammation that may be causing your knees to become dark or reddened

Of note, among the elevated inflammatory mediators, the blood IL-6 level is highly correlated with the disease mortality when COVID-19 survivors and non-survivors are compared [1, 11], suggesting that fatal COVID-19 is characterized as a cytokine release syndrome (CRS) that is induced by a cytokine storm with high mortality [12,13,14]

Close monitoring by a dermatologist is required

Hypothesis: oxidative stress score as a combined measure of pro-oxidant and antioxidant exposures