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Since malignant Tfh cells are present in AITL as the main hallmark, it is possible to account for their hyperactivation as one of the main mechanisms of pre-existing lymphoma recurrence or the beginning of a new lymphoproliferative disease

Conflict of interest JDC has received grants and personal fees from AstraZeneca, Boehringer-Ingelheim, GSK, Zambon, and Insmed Incorporated, a grant from Gilead, and personal fees from Novartis and Chiesi

Some of these symptoms can be treated or managed

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