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The application of oxamate by inhibiting lactate production can convert tumor-infiltrating lymphocyte and CAR-T cell phenotypes to a more potent state, maximizing tumor-killing effects and improving survival rates in GBM mouse models when combined with CAR-T [169]

Moreover, transcriptome-wide association studies (TWAS) combine gene expression profiles with GWAS variants to further identify IBD candidate genes: On one hand, risk variants in intestinal macrophages drive gene expression differences associated with inflammation and immune cell differentiation [180, 181], on the other hand, effect genes involved in stress-immune regulation were identified in the hypothalamus and colonic epithelium, suggesting the role of the neuro-immune axis [182]