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Furthermore, ritlecitinib is contraindicated during pregnancy and lactation, and women of childbearing potential should use effective contraception during therapy and for up to 1 month after discontinuation.17 Clinical evidence for ritlecitinibEfficacy: ALLEGRO phase 2b/3 trial The phase 2b/3 ALLEGRO study (NCT03732807) was a randomized, double-blind, placebo-controlled trial evaluating ritlecitinib in 718 patients aged 12 years with 50% scalp hair loss, assessed using the Severity of Alopecia Tool (SALT) an investigator-rated measure ranging from 0 (no hair loss) to 100 (complete scalp hair loss).8 Patients were randomized to receive 50 or 30mg of ritlecitinib once daily (with or without a 4-week 200mg loading dose regimen), 10mg, or placebo for 24 weeks (Fig

Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world and one of the leading indications for liver transplantation

Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes

New insights into follicular helper T cell response and regulation in autoimmune pathogenesis