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Studies have shown that during the primordial to primary transition stage of follicles in obese mice, ferroptosis and cellular oxygen-related signaling pathways are significantly enriched

According to a recent study (144), the lncRNA HEPFAL acts on SLC7A11 and reduces its expression, resulting in a decrease in the amount of cystine transported into the cell and, as a result, a decrease in the intracellular GSH level, which effectively inhibits the iron apoptosis function of GPX4 and, ultimately, iron apoptosis in tumor cells

They are rendered more hydrophilic by biochemical processes in the hepatocyte, yielding water-soluble products that are exported into plasma or bile by transport proteins located on the hepatocyte membrane and subsequently excreted by the kidney or gastrointestinal tract [19] ( Figure 1 )

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