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Pathway analysis of the dysregulated metabolites allude to perturbations in pentose and glucoronate interconversions, glyoxylate and dicarboxylate metabolism, starch and sucrose metabolism, the citrate cycle, arginine and proline metabolism, and tryptophan metabolism early in APP/PS1 mice compared to controls (132)

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The stimulatory effect of resveratrol on hepatic SHBG expression is particularly interesting because of the beneficial effects that red wine consumption has on reducing risk of the metabolic syndrome, type 2 diabetes and cardiovascular disease 22,23,24,25,26,27,28 , and because plasma SHBG levels are well known to be low in obese individuals at high risk for these diseases

These chemical similarities prompted the scientists to check if raspberry ketones could also be a factor in fat metabolism