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For instance, the association of cationic lipids with EV membranes can enhance cellular uptake efficiency (Nakase and Futaki, 2015), while transferrin-conjugated superparamagnetic particles can endow EVs with magnetic responsiveness for imaging-guided therapy (Neubert and Glumm, 2016

Moreover, due to the positive charge of the N -alkylpyridinium group, the corresponding bioconjugation reagents reveal lower partition coefficients (Octan-1-ol to water, cLog P o/w ), in comparison to other known reagents (Supplementary Fig