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Int J Biol Sci 20(14):5474 Shanko SS, Badessa TS, Tura AM (2024) Method development and validation for the quantitative determination of total flavonoids through the complexation of iron(III) and its application in real sample

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4.5.4.6 Recommendations for future studies To advance amino acid metabolites from associative biomarkers to validated therapeutic targets, the field must prioritize: (1) prospective cohort designs with serial metabolite measurements predating renal function decline