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The transferred miR-451a acts on the 3UTR regions of cell cycle inhibitors such as P19 INK4d and P15 INK4b , allowing for a resumption of the halted cell cycle and an improvement in the EMT [183]

196 GDF15 further promotes fatty acid oxidation and lipid metabolism in skeletal muscle and adipose tissue, facilitating beneficial weight loss and glycemic improvements

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A more recent Phase I safety trial on healthy volunteers was started in 2015 but puzzlingly, the researchers never published the results , and the trial record was marked completed with no data release