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Estrogens influence on ER in the prefrontal cortex modulates the strength of synaptic connections and neuronal excitability, enhancing cognitive flexibility and processing speed [13,20,21]

The specific localization along with intense expression of these enzymes in renal carcinoma has led to the design of kidney-selective prodrugs that bypass earlier steps of the mercapturic acid pathway (GST, GT, and peptidase): these compounds include S -(guanin-6-yl)-L-cysteine ( S -(6-Purinyl)-L-cysteine (Hwang and Elfarra, 1991

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Interestingly, G2 significantly increased plant height, stem diameter, fresh weight, and dry weight of G