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Therapeutic potential of PKC inhibitors in painful diabetic neuropathy

Lipotoxicity: when fat becomes a poison The biochemical abnormalities in type 1 diabetes extend significantly to lipid metabolism, creating a condition called lipotoxicity that synergistically accelerates beta-cell failure

Compared with the well-vascularized midportion, the proximal and distal aspects of the tendon are relatively avascular and are consequently the most common sites of rupture