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The 12mg dose produces the most weight loss at 24.2% average over 48 weeks, but it also carries the highest incidence of GI side effects

45 Interestingly, while UBE1 expression remains unchanged in human heart failure, experimental studies have shown that overexpression of UBE1 or UBE6 in neonatal rat ventricular cardiomyocytes (NRVCMs) increases the ubiquitination of Nav1.5, a major transmembrane protein essential for cardiomyocyte depolarization