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As the treatment with gene therapy modalities, such as mRNA in enzyme replacement therapy, is chronic, accumulating LNPs in tissues over repeated administration may result in adverse health effects

Similarly, reducing the Sirtuin activity with inhibitors (EX-527) during the second hypo-inflammatory stages may reverse the hibernating endothelium and vasculature, improve neutrophilic function, clear the debris, aid with effective oxidative phosphorylation and mitochondrial biogenesis, and healing, and may improve survival [11, 49]

Vitamin C: Essential for the body development and function, also plays an important role in immune function

This section summarizes the newest research on diagnostic approaches for MDD, including serum indicators, neuroimaging indicators and multimodality scales