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Furthermore, MC4R-deficient mice develop severe obesity accompanied by markedly elevated plasma leptin concentrations and leptin resistance, failing to respond to leptins anorectic and cardiovascular effects [58, 59]

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When reduced forms of coenzyme Q 10 (CoQ 10 H 2 ), vitamin C (ascorbate), or glutathione (GSH) reduce oxidized -tocopherol (-TO), they themselves become oxidized (ubisemiquinone, dehydroascorbate, or GSSG)