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The primary injury results in localized brain damage, while the secondary damage initiates inflammatory responses, followed by the disruption of the blood-brain barrier, infiltration of peripheral blood cells, brain edema, and the release of various immune mediators, including chemotactic factors and interleukins

DCR-MYC or DCR-M1711 (Dicerna Pharmaceuticals), is a Dicer substrate siRNA (DsiRNA) encapsulated in EnCore LNP to downregulate c-Myc across multiple solid tumors