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After crossing the BBB, lead accumulates in astroglial cells (containing lead binding proteins)

Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs)

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76 (7), 1184

This disparity is hypothesized to arise from differences in estrogen-mediated neuroprotection, lifestyle factors, and occupational exposure to neurotoxins (Ben-Shlomo et al., 2024) (Figure 2)