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This modification is orchestrated by a group of enzymes, predominantly kinases, which catalyze the addition of phosphate groups to specific protein residues

Abnormal neutrophil recruitment in CF airways increases oxidative stress, causing redox imbalance and elastase/IL-8 release

But how

Mackay-Wiggan J, Sallee BN, Chun Wang EH, Sansaricq F, Nguyen N, Kim C, Chen JC, Christiano AM, Clynes R (2020) An open-label study evaluating the efficacy of abatacept in alopecia areata