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For example, excitatory/inhibitory balance has been recognized as central to communication between neurons

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In experimental models of cerebral ischaemia, DSIP administration was associated with accelerated restoration of motor coordination and reduced neuronal damage, with proposed mechanisms involving stabilisation of neuronal membrane function and protection against excitotoxicity from excessive glutamate signalling

2021;16(3):e0247307

Important milestones in the GHK-Cu literature include the original 1973 identification of GHK as a plasma-derived cell proliferation factor, the recognition of the copper-binding role in the late 1970s, the wound healing and collagen research of the 1980s and 1990s, the establishment of GHK-Cu as a cosmetic ingredient in the 1990s and 2000s, and the transcriptomic expansion of the research literature in the 2000s and 2010s