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Upon entering systemic circulation and reaching bone tissue, 5-HT attaches to the 5-HTR1B receptor on osteoblasts, which inhibits cAMP response element-binding protein (CREB) activity and cyclin expression, thereby suppressing osteoblast proliferation and differentiation and ultimately hindering bone formation (256)

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Analysis of senescent cells damaged in the upper dermis revealed the presence of p38 MAPK, highlighting the significance of senescence in the continual pigmentation seen in melasma