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A cohort study of T2DM patients ( n = 126) and non-T2DM ( n = 1,228) found that cognitive dysfunction in T2DM patients on metformin therapy is associated with low B12 serum levels (186)

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Additional studies, particularly prospective cohort studies, are needed to verify the causality, determine the generalizability to other countries, and elucidate the underlying mechanism.

Single nucleotide variants (SNVs) and small insertions and deletions (indels) were generated with the Genome Analysis Toolkit (GATK) pipeline and annotated with ANNOVAR