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The knockdown also changes correlations of the levels of OGDHC, GDH and GOT2 with those of the malate and isocitrate dehydrogenases

Furthermore, many chelators lack selectivity for copper over other essential metals, causing off-target depletion of ions such as zinc and iron, which compounds their toxicity [242]

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64,66 This metabolic disorder not only affects the energy supply of oocytes but also alters the balance of intracellular metabolic products, affecting cellular signaling and gene expression, ultimately leading to abnormal follicular development and a decline in oocyte quality

Abstract 4135531: The ubiquitin-specific protease 30 inhibitor, MTX652, attenuates cardiac dysfunction and remodelling in a murine model of transverse aortic constriction