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doi: 10.1002/marc.202400495 78 WangLYeSQinJTangMDongMYFangJ

Multiple Sclerosis Pathology

Some clinics promote injections like: Lipotropic injections (fat burners with B12 and amino acids) HCG injections (used with a very low-calorie diet) B12 injections (boost energy and metabolism) However, these are not FDA-approved for weight loss and lack strong clinical evidence

Biological age and telomere lengths were measured at baseline, 9 months, and 16 months using TruAge

Conditions associated with elevated B12 levels include: Liver disease : Hepatocellular damage releases stored B12 into circulation, with levels correlating with disease severity in conditions such as cirrhosis, hepatitis, and hepatocellular carcinoma Renal impairment : Reduced kidney function decreases B12 clearance, leading to accumulation Haematological malignancies : Myeloproliferative disorders, acute leukaemia, and polycythaemia vera can elevate B12 through increased production of B12-binding proteins (transcobalamins) Solid tumours : Certain cancers, particularly those affecting the liver or gastrointestinal tract, may elevate B12 levels A specific concern relates to cyanocobalamin in patients with Leber's hereditary optic neuropathy , a rare mitochondrial disorder