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First, the small numbers to the left of each circle are the hole numbers, so we are looking (clockwise) at holes 1, 7, 8, 2

it modulates TGF- (anti-fibrotic) and influences Wnt (neo-folliculogenesis)

doi: 10.1016/0003-2697(88)90048-6

AMY1R and AMY3R are the predominant subtypes expressed in the area postrema and hypothalamic nuclei relevant to energy balance regulation (Hay et al., British Journal of Pharmacology, 2015)