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Burianov 1 , A

All groups were maintained under standard laboratory conditions (12-hour light/dark cycle, temperature 22 1 C, and free access to food and water)

Transport of cyclic nucleotides and estradiol 17--D-glucuronide by multidrug resistance protein 4: resistance to 6-mercaptopurine and 6thioguanine

These findings provide a basis for the potential use of GSH as a therapeutic method for SAE.

In the Ames test, a biological assay assessing mutagenicity using isolated bacteria in food system from chemicals causing DNA mutation, milk kefir was able to lower the mutagenicity rate of methyl methanesulfonate and sodium azide by a difference of 25% and 21% respectively, as compared to unfermented milk, suggesting the potential of milk kefir preventing DNA damage caused by mutagens (Guzel-Seydim et al., 2006)