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For the surface-confined nucleic acids (ADC), introduction of siRNAs leads to the rigid double-stranded structure and the more crowded geometries although not changing the length of nucleotide strands

The idea is that this invader will reach the liver cells, and the enclosed gene will initiate production of the protein that would normally restore proper copper metabolism

The effects typically start within a few days, peaking as glutathione levels rise in the bloodstream

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Other members of the DmrtA family, such as Dmrt3 and Dmrta1, were also efficiently recovered, which is expected given the ability of DmrtA proteins to bind DNA, forming homo- and heterodimers, trimers, or tetramers (Murphy et al., 2007, 2015)