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J Steroid Biochem Mol Biol (2010) 121(1-2):8897

The sulfurylation of DS and CS typically occur at positions 4 and 6 of the N-acetylgalactosamine (GalNAc) residues

The chances are, there are multiple triggers and since we have different genetics, immune systems, and other factors at play, people are likely reacting to different things