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Nature medicine 2016;22, 7883, doi: Schoenwaelder, S

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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, HIV infection, AIDS, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

Other factors were not addressed in the study, such as increased awareness of good vaccination practice, not injecting cold vaccines, and vaccinating only if necessary (e.g., Switzerland became rabies-free in 1999)

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