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97,98 Parks team demonstrated that saponin extract exposure dramatically decreased miR-21-5p expression in HESCs and upregulated caspase-3 expression, which in turn promoted cell apoptosis

I , Density of EdU+ cells (cells/m 2 10 4 ) in the dentate gyrus (unpaired t test, t (21) = 1.043, p = 0.3090)

Approaches used allow a comparison of species to identify those that may be more sensitive than others (e.g., see Section 6.7.2.5 on CAFE) or are able to predict the toxicity of oil and its constituents to species that have not yet been studied (e.g., see Section 6.7.2.6 on ICE)