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These specific or secondary granules are composed of an electron-dense core and a less electron dense matrix, the core being a crystalline lattice by electron microscopy

10.1073/pnas.94.4.1441 222 YamamotoC.YagiS.HoriT.IidaT.TaniguchiK.IsajiS.et al (2010)

[14] More serious side effects are less common but medically important

Magnetic resonance imaging showed that iron deposition is correlated with cognitive impairment, and this deposition is mainly observed in the hippocampus, cortex, and basal ganglia, where brain cells experience oxidative stress, lipid peroxidation, and increased cystine/Glu transporter expression, iron metabolism, and balance (Ghadery et al., 2015

As a non-limiting example, the release of the antibody compositions may be provided by an acid-labile linker such as, but not limited to, those described in U.S