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Survival experiments were tested with log-rank (MantelCox) test and distributions with MannWhitney test

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The rationale is: First course: Addresses the existing senescent cell burden

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Hepatology 40:961971 Fannin RD, Russo M, OConnell TM, Gerrish K, Winnike JH, Macdonald J, Newton J, Malik S, Sieber SO, Parker J, Shah R, Zhou T, Watkins PB, Paules RS (2010) Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation

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