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J Nanobiotechnol 19:109

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Although peripheral 5-HT cannot cross the BBB directly, it influences CNS function indirectly by activating vagal afferent fibers, modulating immune cells, and affecting tryptophan availability ( 4.1.2 The GABA pathway Beyond the 5-HT system, GABA, as the most abundant inhibitory neurotransmitter in the CNS, has a core role in mood regulation and anxiety control