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Subsequent interest in AOD-9604 has been limited to niche research areas, particularly osteoarthritis, where intra-articular injection might bypass systemic bioavailability limitations

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We have bathed her twice, applied medication twice and the fleas persist. This pattern extends to veterinary medicine, where extended or improperly managed antibiotic courses in dogs treating chronic conditions such as recurrent skin infections contribute to antimicrobial resistance (21)

doi: 10.7554/eLife.17834