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(3) Ferroptosis not only induces tumor cell death but also modulates the immune landscape by releasing damage-associated molecular patterns (DAMPs) and reactive oxygen species (ROS), enhancing T-cell activation and tumor-associated macrophage (TAM) polarization toward an anti-tumor phenotype [9]

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There is considerable sequence similarity between rat 4- N -trimethylaminobutyraldehyde dehydrogenase and human aldehyde dehydrogenase 9, [23] but the true identity of 4- N -trimethylaminobutyraldehyde dehydrogenase remains to be established