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Furthermore, intramuscular injections carry higher risks, require a longer and thicker needle (which goes against everything we've just discussed), and can be significantly more painful

As the largest organ and a vital barrier separating the bodys internal environment from the external milieu, the skin is constantly exposed to a variety of external substances, leading to the generation of oxidative and inflammatory mediators (36)

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For instance, in Arabidopsis , impaired MDAR4 function decreased the AsA/DHA ratio without affecting the ASC content, but substantially impaired plant oxidative stress tolerance (Eastmond, 2007)

This is problematic, as treatments aiming to increase Hb levels by a few grams per deciliter are clearly more promising for the treatment of patients with thalassemia intermedia than for the treatment of transfusion-dependent patients