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The main roles of the complement activation are (1) opsonization of microbes and promoting phagocytosis, (2) triggering of inflammation process after diffusion of complement components away from the site of activation, (3) elimination of large immune complexes from the blood, and (4) membrane rupture of foreign cells

It depends on the clinical picture of the disease

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Potassium and magnesium may need attention too

This is because refrigeration only slows degradation but does not prevent it