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M.MaesL.et al (2020)

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Understanding the interconnection between local (microenviroment) and remote (emergency myelopoiesis) mechanisms of HO-1 regulation could improve our ability to therapeutically target its functions in disease, also considering its dynamic and stage-dependent activity observed in distinct pathological contexts

Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses

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