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1 Introduction Hyperammonemia is a common complication of neonatal organic acidemia, with approximately 61.5% of patients developing hyperammonemia ( Carglumic acid, a structural analog of N-acetylglutamic acid, was granted approval in Europe in 2003 for the treatment of inherited metabolic disorders, including N-acetylglutamate synthase deficiency and organic acidemia

), taurine, L-Carnitine, preservatives (potassium sorbate, sodium benzoate), sweeteners (acesulfame K, sucralose), caffeine

Results showed that T1DM significantly elevated oxidative stress markers, pro-inflammatory cytokines, and miRNA expression while reducing TAC, testosterone, sperm count, and Johnsons score

doi: 10.1038/s41579-020-0433-9 8 GruppenEGGarciaEConnellyMAJeyarajahEJOtvosJDBakkerSJLet al

10.1271/bbb.70514 Biosci., Biotechnol., Biochem