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Patients should be monitored for changes in the effectiveness of their diuretic therapy and for signs and symptoms of renal impairment

Its structural domain has been identified (Zheng et al., 2019), and is likely a disease-inducing mechanism ( 3 Relationship of Piezo1 to the CNS As a class of cation-selective channels, Piezo1 responds to mechanical stimuli and is activated and rapidly inactivated in a voltage-dependent manner (Moroni et al., 2018)

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In this context, the subcutaneous LDopa infusion pump could offer an intermediate approach between the two conventional administration routes of LDopa, potentially mitigating some side effects