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The hyper-coiled, heavily cross-linked, and chemically stable collagen components of the ECM have a half-life longer than the average human lifespan if not actively degraded by Schwann cells and fibroblasts, blocks immune cell migration and drug diffusion, and induces pro-tumorigenic signaling

FASEB J 29(6):25662582 Karolczak K, Watala C (2019) The mystery behind the pineal gland: melatonin affects the metabolism of cholesterol

however, in other cases, it results in a dysfunctional immune response, which can cause serious pulmonary, and even systemic, pathology [5,6,7]

Some begin with a strong physiologic rationale, narrower clinical studies, and accumulating experience in carefully selected patients

[DOI] [PMC free article] [PubMed] [Google Scholar] Plavec T