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The activation of ferroptosis by erastin promotes chaperone-mediated autophagy and the degradation of glutathione peroxidase 4 (GPX4) (180)

Glutathione is the molecule of purification and antioxidant protection: it works on the liver, free radicals, and skin appearance, indicated when the aim is to detoxify the organism and visibly improve luminosity and complexion uniformity

The activation of this pathway is characterized by the upregulation of pro-apoptotic proteins such as Bax, inhibition of anti-apoptotic proteins like Bcl-2, and the release of Cyt-c from mitochondria into the cytosol [73, 161]

doi: 10.3382/ps.2011-01951 154

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