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Eur Heart J 24: 18151823, 2003 [DOI] [PubMed] [Google Scholar] 133.Moustafa ME, Carlson BA, El-Saadani MA, Kryukov GV, Sun QA, Harney JW, Hill KE, Combs GF, Feigenbaum L, Mansur DB, Burk RF, Berry MJ, Diamond AM, Lee BJ, Gladyshev VN, and Hatfield DL

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While clinically useful, this classification has been increasingly questioned due to its reliance on arbitrary time cutoffs and its inability to reflect the underlying biological diversity of resistance mechanisms [11,12,13]