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FREQUENCY OF USE OF THE TERM CIGARETTE SMOKE OVER TIME The graph expresses the annual evolution of the frequency of use of the word cigarette smoke during the past 500 years

These results are in accordance with our previous study showing that smoking negatively alters the sperm standard parameters, DNA stability of sperm, and the ratio of protamine mRNA as well as downregulates the expression of H2BFWT, PRM1, and PRM2 36

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Furthermore, the National Tobacco Control Strategy, following the WHO FCTC guidelines, utilizes a top-down policy approach with a National Tobacco Control Committee guiding policy decisions