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Autoantibodies have been identified which interfere with the ability of the FR to function

Light Sci Appl 15 , 116 (2026)

A recent study testing the effects of folate and cobalamin supplementation in a mouse model of heart failure induced by pressure overload showed that left ventricle ejection fraction was preserved in mice fed with food supplemented with folate and cobalamin [232]

doi: 10.1016/j.cellsig.2018.02.006 33 DewhurstJALeaSHardakerEDungwaJVRaviAKSinghD

This protective effect was further validated during parthenogenetic activation, where aged oocytes displayed a fragmentation rate reduction of approximately 27% following Epitalon treatment