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Furthermore, technologies such as microfluidics or flash nanoprecipitation should be explored as they offer greater control over nanoparticle size and composition to ensure consistent biological response and GMP compliance 145,148,149

An overview of the glutamatergic signaling pathways described above is depicted in Figure 1

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The limits of passive targeting techniques are highlighted by thorough assessments of nanoparticle delivery efficiency, which have revealed that, on average, less than 1% of the injected nanoparticle dosage penetrates solid tumors [11, 12]