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HDL METABOLISM AND REVERSE CHOLESTEROL TRANSPORT All nucleated cells synthesize cholesterol, but only hepatocytes and enterocytes can effectively excrete cholesterol from the body, into either the bile or the gut lumen

Nonetheless, also unsaturated fatty acids have been associated with pro-inflammatory responses in macrophages: atherosclerotic lesions from hyperlipidemic mice were shown to be highly abundant in the mono-unsaturated fatty acid oleic acid and the omega-6 PUFAs linoleic acid and arachidonic acid, which in contrast to the saturated fatty acids palmitic acid or stearic acid - could trigger inflammasome-independent IL-1 production in macrophages

In vivo and in vitro models show that medium-chain triglycerides led to greater damage and colitis symptoms, while the use of HT with eicosapentaenoic acid and docosahexaenoic acid significantly reduced damage and inflammation, as well as the combined use of fish and olive oil [550]

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