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J., Stewart, E

Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design

Furthermore, recent studies identify the involvement of a kidneybrain axis, wherein renal dysfunction may exacerbate neurodegeneration through impaired clearance of neurotoxic metabolites, chronic systemic inflammation, and metabolic dysregulation [32, 33, 34]

These results validated that ZZW-115 worked efficiently in blocking the nuclear translocation of NUPR1 in our culture model and that inhibition of NUPR1 nuclear translocation induces cell death in phBECs, indicating an important protective role in bronchial epithelial cells

Forty-nine biopsies (40%) were from follow-ups